Connelly M, et al. - Researchers performed a retrospective chart review of 36 patients ages 11-18 with refractory migraine who were treated with outpatient dihydroergotamine (DHE) infusion with interdisciplinary adjunctive care in an outpatient neurology clinic in order to determine preliminary outcomes of this treatment for refractory pediatric migraine. The analysis revealed a decline in headache intensity (M = 5.8 ± 2.5 to M = 2.4 ± 2.7) during the treatment period and this improvement remained statistically significantly through 3-month follow-up. Findings thereby support the promising value of combining outpatient DHE infusion with interdisciplinary adjunctive care as an efficient treatment option for adolescents with refractory migraine.