Beaumont H, Maas M, Wormanns D, et al. - This study was undertaken to investigate the 3D version of vertebral disk ratio (VDR), namely enhanced vertebra disk radio (eVDR), and examine the performances of two eVDR–derived response criteria for GD patients. Researchers applied three datasets: 8 longitudinal GD patients, 13 non-GD patients, and 2 longitudinal GD patients with known bone marrow burden scores. They further investigated two eVDR-derived response criteria: a parametric version (PeVDR) averaging all eVDR measures recorded for the 5 lumbar vertebrae; and a non-parametric version (NPeVDR), considering all eVDR measures as independent and evaluating therapeutic response in a paired fashion. The eVDR imaging biomarker and its derived response criteria improved GD evaluations and could help evaluating other bone marrow diseases, based on a standard MRI sequence.