Königstein K, Wagner J, Frei M, et al. - This study sought to provide reference values and to evaluate the predictive value of low flow-mediated constriction (L-FMC), flow-mediated dilation (FMD) and their composite endpoint vasoactive range (VAR) in healthy adults. Researchers assessed L-FMC, FMD and VAR in 457 nonsmoking adults of 20–91 years without chronic diseases, medication, with normal heart function and very low cardiovascular risk. They calculated gender-specific percentiles and predictive ability for elevated cardiovascular risk was evaluated using receiver-operating characteristic curves. The results revealed decreased endothelial function with aging in healthy men and women with very low cardiovascular risk. The outcomes of this research showed that percentiles crossed cut-offs for elevated cardiovascular risk between 50 and 55 years in men and 70 and 75 years in women, demonstrating higher risk for cardiovascular disease in men. As per the findings, VAR showed the highest ability to distinguish individuals with elevated cardiovascular risk, and should be included in the monitoring and treatment of accelerated vascular aging even in healthy individuals.