Mendoza-Pinto C, Rojas-Villarraga A, Molano-González N, et al. - Researchers analyzed reports of cardiovascular disease in systemic lupus erythematosus (SLE) patients, as measured by endothelial dysfunction (ED) and arterial stiffness (AS), by performing a systematic review and meta-analysis. From PubMed, Cochrane library, EMBASE, VHL, SciELO and Web of Science databases, they identified studies examining the link of SLE with ED (flow-mediated dilatation [FMD], nitroglycerin-mediated dilatation and peripheral arterial tonometry) and AS (augmentation index, pulse wave velocity). A meta-analysis with 49 studies was performed. Findings revealed impaired FMD, which is an independent predictor of cardiovascular events, in SLE patients. SLE patients vs controls showed a higher degree of AS. Considering ED and AS in SLE is recommended when planning preventive strategies and treatments.