Shah SJ, Abuzeid WM, Ponduri A, et al. - In aspirin-exacerbated respiratory disease (AERD) patients who initially failed aspirin therapy, researchers ascertained if recent endoscopic sinus surgery (ESS) improved aspirin treatment outcomes. They identified 19 patients who benefited (responders) and 21 patients who failed (nonresponders) preoperative aspirin treatment with a distant history of ESS (mean, 48 months). The primary aspirin therapy was linked to a significant rise in IgE in nonresponders, but after the second aspirin desensitization and treatment, there was no significant rise in IgE. Findings suggested that antecedent ESS enhances aspirin treatment responses in patients with AERD and can convert patients who failed aspirin treatment before surgery to a more responsive phenotype after ESS. The ESS performed shortly before aspirin desensitization and therapy can benefit patients with higher baseline serum IgE levels.