Green RW, et al. - Researchers assessed the extent to which two-dimensional transvaginal ultrasound (2D-TVS) and three-dimensional volume contrast imaging (3D-VCI) show agreement in diagnosing deep myometrial invasion (MI) and cervical stromal involvement (CSI) of endometrial cancer. They also compared inter-rater reliability and diagnostic accuracy of the two methods. The estimated agreement between 2D-TVU and 3D-VCI for diagnosing MI was median 76% (range 64–93%) and for CSI median 88% (range 79–97%). Use of 3D-VCI vs 2D-TVU video clip for off-line assessment of MI and CSI in women with endometrial cancer had lower interrater reliability and lower accuracy. They recommended these examinations be centralized to high-volume centers, as the accuracy was found to be correlated to the number of cases assessed annually.