Konda B, et al. - In this case-based review, the physicians intended to present clinical presentation, diagnosis, and management strategies of immune-related endocrinopathies associated with immune checkpoint inhibitors use. The results of this study displayed that immune checkpoint inhibitors use is associated with serious endocrinopathies that may have a nonspecific initial presentation. In addition, a constant eye for these symptoms and a systematic approach to diagnosis are essential for prompt initiation of therapy and prevention of significant complications.