Siow I, Lee KS, Zhang JJY, et al. - In view of the growing number of reported cases of encephalitis related to COVID-19 infection, researchers herein conducted a systematic review and meta-analysis investigating the incidence, clinical course, and outcomes of these patients. Of 610 screened studies, they included 23 studies reporting findings from 129,008 patients, including 138 with encephalitis. The average time of 14.5 days (range = 10.8–18.2 days) was recorded for the onset of encephalitis from diagnosis of COVID-19. Encephalitis as a complication of COVID-19 showed an average incidence of 0.215%. Deranged clinical parameters, including raised serum inflammatory markers and cerebrospinal fluid pleocytosis, were also recorded in these patients. Overall findings suggest that encephalitis results in significant morbidity and mortality, when present as a complication of COVID-19. Risk of suffering from encephalitis as a complication of the COVID-19 was noted to be higher in severely ill patients.