Emphasis on systemic therapy in women with pelvic bone metastasis at time of diagnosis of cervical cancer
American Journal of Clinical Oncology Oct 30, 2018
Manders DB, et al. - Given that cervical cancer presenting with metastases to the bony pelvis is rarely seen, researchers analyzed their experience treating women with this infrequent presentation via a review of all patients treated for cervical cancer at a single institution between January 1, 2007 and November 30, 2014. The study sample included patients who had evidence of pelvic bone metastases by imaging before the beginning of treatment. In patients who received palliative rather than curative radiotherapy, and in those who received any postradiation chemotherapy, survival was statistically comparable. Data reported that cervical cancer metastatic to the bony pelvis at initial presentation predicts a bleak prognosis. When considering curative-intent vs palliative treatment, patients ought to be educated about this poor prognosis and allowed to make an informed decision. Findings suggested that bevacizumab seems to improve survival.
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