Li J, Zhong Y, Ma Z, et al. - The present study was conducted to distinguish the variation in the prefrontal cortex (PFC)-limbic circuitry response to emotional stimuli between generalized anxiety disorder (GAD) patients and healthy controls (HCs) from the perspective of the brain network. Individuals were needed to complete an emotional face identification task (fearful, neutral, happy facial expression) during fMRI scanning. Researchers recruited a total of 30 participants (16 GAD patients, 14 HCs) in the formal analysis. The brain network consisting of several pre-hypothesized regions of interest under each condition (negative, positive, neutral) was distinguished using a Bayesian-network based method. The results considered that more bottom-up connection but the less top-down connection may demonstrate that GAD patients are insufficient in top-down control, in keeping with the inadequate top-down control hypothesis. In interoception processing, the more connected insula may indicate GAD patients’ abnormality. Relative to HCs, it was shown that distinct brain network response pattern in GAD patients under neutral condition implies GAD patients’ abnormality in distinguishing safety from threat and intolerance of uncertainty.