Tripathi R, et al. - Population-level estimates regarding scabies visits to American emergency departments (EDs)were determined via performing a retrospective analysis of the nationally-representative National Emergency Department Sample from 2013 to 2015. Among 416,017,218 included ED visits, 356 267 were due to scabies (prevalence = 85.7 per 100,000 ED visits). The average annual expenditure of $67,125,780.36 was reported for scabies ED visits. Most frequently male children from lower-income quartiles comprised the patients visiting the ED for scabies; these patients tended to present to the ED on weekdays in the fall, controlling for all other factors. Admission as inpatients was most likely for scabies ED patients that were male, older, insured by Medicare, from the highest income quartile, and from the Midwest/West. The greatest cost of care was incurred by older, higher income, Medicare patients in large Northeastern metropolitan cities. These findings may have implications in the development of targeted interventions to reduce the incidence and burden of scabies in American EDs.