Yu Q, et al. - In a Chinese population with metastatic colorectal cancer (mCRC), researchers determined the link between UDP-glucuronosyltransferase (UGT)1A polymorphisms and irinotecan-treatment efficacy. They used Kaplan–Meier and Cox regression analyses to examine the link between potential signatures and survival outcome. They found that UGT1A1*28 variant genotype vs wild-type genotype was significantly related to decreased progression-free survival (PFS) and overall survival (OS). Overall, survival outcome of irinotecan-treated Chinese mCRC patients could be predicted by UGT1A polymorphisms. UGT1A polymorphisms, if validated, might assist in facilitating stratification of mCRC patients for individualized treatment options.