TXNDC5 contributes to rheumatoid arthritis by down-regulating IGFBP1 expression
Clinical and Experimental Immunology Nov 17, 2017
Li J, et al. - In order to investigate if thioredoxin domain-containing 5 (TXNDC5) contributes to rheumatoid arthritis (RA) via the insulin signaling pathway, researchers performed this study. Findings indicated that by inhibiting insulin-like growth factor binding protein 1 (IGFBP1) expression, TXNDC5 contributes to abnormal RA synovial fibroblast-like cell (RASF) proliferation, migration and IL-6 production.
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