Feng A, et al. - Researchers investigated sphingosine-1-phosphate (S1P) receptor 1 (S1PR1)-related biomarkers capable of predicting survival of patients with sepsis utilizing gene expression profiles of peripheral blood to be used as potential prognostic and diagnostic instruments. This study included sepsis patients enrolled in published datasets from Gene Expression Omnibus. They discovered 62-gene and 16-gene S1PR1-associated molecular signatures (SMS) related to the survival of patients with sepsis in the discovery cohort. Significant enrichment of both SMS genes in many key immunity-associated pathways that are known to have important roles in sepsis development was evident. Meanwhile, good performance of SMS was noted in a validation cohort including sepsis patients. Overall, it was proved that S1PR1-dependent genes have significant involvement in sepsis development, and novel gene signatures for predicting survival of sepsis patients were afforded in this work.