Chou A, Brown IS, Kumarasinghe MP, et al. - Fluorescent in-situ hybridization (FISH) studies on a cohort of 40 acinar cell spectrum tumors including 36 pure acinar cell carcinomas, three pancreatoblastomas, and one mixed acinar-pancreatic neuroendocrine tumor was done to test the hypothesis that RET gene rearrangements may be prevalent in acinar cell carcinomas, provided its novel molecular profile. RET gene rearrangements were distinguished in three cases whereas BRAF gene rearrangements were recognized in five cases. Each gene rearranged tumors were absolute acinar cell carcinomas. Hence, the findings of these studies indicate that among all pancreatic carcinomas, acinar carcinomas are profoundly enriched for probably actionable gene rearrangements in RET or BRAF. Further, FISH testing is cheap and easily available in the routine clinical setting and may have a part in the evaluation of all acinar cell carcinomas—at this stage in order to enroll individuals for clinical trials of fresh targeted therapies, although possibly in the near future as a component of routine care.