Houcken J, et al. - Given that single nucleotide polymorphisms (SNPs) of various genes increase susceptibility to monoglandular autoimmunity, researchers assessed potential associations of eight SNPs with autoimmune polyglandular syndromes (APSs). This study comprised 543 patients with APS and monoglandular autoimmunity and controls. The results obtained from the study indicate that protein tyrosine phosphatase nonreceptor type 22 (PTPN22) and cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) polymorphisms were correlated with APS and differentiate between polyglandular and monoglandular autoimmunity.