Mehrad M, et al. - The prognostic significance of clinicopathologic and genetic characteristics of pulmonary sarcomatoid carcinoma (PSC) was determined. Based on the results, it was determined that copy number gains were noted in EGFR (2/23, 13.0%), and in 1 (4.3%) each of PIK3CA, KRAS, MET, and STK11. The detection of potentially targetable mutations was possible in a subset of PSC, although most tumors harbored currently untargetable prognostically adverse TP53 and KRAS mutations.