Domanski L, et al. - In this study including 82 patients who had undergone renal graft transplantation and kidney biopsy due to impaired graft function, researchers assessed the association of rs2275913 IL17A and rs2397084, rs11465553 and rs763780 IL17F gene polymorphisms with histopathological alterations in transplanted kidney biopsies such as: glomerulitis, tubulitis, arteritis, cell infilitration and fibrosis. Findings revealed a significant association of the rs2275913 IL17A gene polymorphism with the grade of tubulitis (which was more severe among A allele carriers vs recipients with the GG genotype), and with the grade of arteriolar hyaline thickening and mesangial matrix increase (which were more severe among patients carrying G allele vs recipients with the AA genotype). Among subjects with the C allele at the rs763780 IL17F gene polymorphism, more severe tubular atrophy and interstitial fibrosis were detected. A possible link between the rs2275913 IL17A and rs2275913 IL17A gene polymorphisms and some histopathological alterations in transplanted kidney biopsies could be suggested in this study.