Xiao S, et al. - Experts studied the effect of differing Helicobacter pylori status (H. pylori negative, H. pylori eradication, and H. pylori persistence) on the development of metachronous gastric lesions following endoscopic resection of early gastric cancer in this systematic review and meta-analysis. Results indicated that eradication of H. pylori can provide protection against secondary gastric neoplasm, and this quantitative benefit appeared greater than among asymptomatic people. Findings revealed that metachronous risk seems similar between H. pylori-eradicated and -negative population, or between H. pylori-negative and -persistent patients.