Cheng KP, et al. - In this investigation, researchers studied the effect of Helicobacter pylori infection status and its eradication on glycemic control and antidiabetic therapy among patients with type 2 diabetes. In total, 549 diabetic patients were enlisted for sequential two-step approach (IgG serology followed by ¹³C-urea breath test, UBT) to distinguish “active” (IgG+ and UBT+) from “non-active” (UBT- or IgG-) H. pylori infection, and “past” (IgG+ but UBT-) from “never/remote” (IgG-) infection. According to findings, diabetic patients with active H. pylori infection need a higher intensity of glycemic treatment to achieve comparable glycemia. In addition, the eradication of H. pylori reduces A1C and, thus, improves glycemic control.