Liau JY, Tsai JH, Lan J, et al. - In this study, experts examined the clinicopathological and molecular characteristics of 26 anastomosing hemangiomas (AHs, a separate benign vascular tumor that could be histologically confused with an angiosarcoma). Through Sanger sequencing and MassARRAY analysis, of the 22 reviewed tumors, mutually exclusive mutations in exon 5 of GNA11, GNAQ and GNA14 were recognized in 10, 5, and 5 tumors, respectively, with an overall mutation rate of 91%. Between GNA11-, GNAQ- or GNA14-mutated tumors, no important variations in the clinicopathological peculiarities were noted. Results showed GNA11 mutations and formerly known mutations of its paralogues GNAQ and GNA14, as necessary drivers in the pathogenesis of AH.