Zou C, et al. - Given that the CTLA4 gene has been implicated in the development of colorectal cancer (CRC), researchers examined 1,003 sporadic CRC cases and 1,303 controls in order to study the association between CTLA-4 polymorphisms and CRC risk. For this purpose, they genotyped four CTLA-4 tagging polymorphisms and calculated crude/adjusted ORs with their 95% CIs. They found an increased risk of CRC in relation to the presence of CTLA-4 rs231775 G>A polymorphism. In haplotype comparison analysis, CRC risk was seen to be increased by CTLA-4 G_rs3087243C_rs16840252 C_rs733618 A_rs231775, G_rs3087243 C_rs16840252 T_rs733618A_rs231775, and other haplotypes. Overall, this study offers evidence for an association of CTLA-4 tagging polymorphisms and haplotypes with CRC risk.