Cusini, A, et al. - Within the Swiss Transplant Cohort Study (STCS), researchers assessed the incidence, risk factors and outcome of Clostridium difficile infection (CDI). Multivariable analysis revealed that proven infections and antibiotic treatments during the preceding three months had an independent association with the development of CDI. Despite mild clinical presentations, recipients acquiring CDI post-transplantation had an increased risk of graft loss. Findings could assist in improving the management of solid organ transplant recipients.