Diaz-Rubio GI, Corona-Meraz FI, Madrigal-Ruiz PM, et al. - Researchers intended to determine if there is an association between the relative expression of CCR2 and CMKLR1 and the serum levels of their ligands CCL2 and RvE1, in the context of adiposity status with insulin resistance (IR) as a comorbidity in rheumatoid arthritis (RA). Participants in the study were 138 controls and 138 RA-patients classified with and without IR. The authors conclude that in RA with IR, the chemokine receptors expression pattern exhibited a parallel increase with their respective ligands. Chronic inflammation could be intensified by RA and IR in combination with the pathological distribution of body fat mass. Such findings indicate that high levels of CCL2 and compensatory levels of RvE1 may not be appropriate for the inflammation to be resolved on its own.