Yan S, et al. - Investigators analyzed 145 individuals to examine the consequences of C reactive protein (CRP) polymorphisms on the susceptibility and therapeutic efficiency in chronic spontaneous urticaria (CSU) cases. They determined the CRP rs3093059T/C and rs2794521G/A genotypes of candidates by Sequenom MassARRAY. They conducted relative luciferase assay and β-Hexosaminidase assay in HEK293T cells or RBL-2H3 cells to study the function of variants. Mizolastine influenced 62.50% of total cases whereas 72.4% of candidates revealed impacts in the desloratadine group. They observed a significant association between cases with rs3093059TT genotype and good response as they had lower serum CRP, IL-6 and TNF-α levels than the CT/CC genotypes. Inhibiting degranulation effects by mizolastine were noted in β-Hexosaminidase assay. This effect was observed weak when mizolastine with a higher dose of CRP in RBL-2H3 cells was implemented.