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BRCA testing in unaffected young women in the United States, 2006-2017

Cancer Oct 09, 2019

Guo F, et al. - Among women younger than 40 years without diagnosed breast or ovarian cancer (unaffected young women [UYW]) in the United States, researchers analyzed trends in BRCA testing for cancer prevention for a duration from 2006 to 2017. Using the de-identified Optum Clinformatics Data Mart database, they selected 93,278 adult women 18 to 65 years old with insurance claims for BRCA testing between 2006 and 2017. They analyzed data comprising medical claims and administrative information from privately insured people in the US. The performance of only 10.5% of the tests in UYW was reported in 2006. In 2017, a significant rise to 25.5% was reported in the proportion of BRCA tests performed in UYW. Taking the area of residence and family history of breast or ovarian cancer into account, a significant variation was evident in the raised trend in the proportion of BRCA tests in UYW. There is a requirement for additional efforts to maximize the early identification of women with BRCA pathogenic variants in order to avert these cancers.
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