Zhang J, Hoedt EC, Liu Q, et al. - This study was undertaken to evaluate the genomic and functional role of  Proteusas a gut pathogen in Crohn’s disease (CD). Proteus spp. abundance was assessed by ure gene-specific PCR in 54 pairs of fecal samples and 101 intestinal biopsies from CD patients and healthy controls. Via RNA seq and KEGG pathway analysis, intracellular gene expression profiles and regulated pathways were examined. This study's findings demonstrate that in the gut, P. mirabilis is correlated with CD and can induce inflammation in cells and animal models of colitis. P. mirabilis may act as a pathobiont and play a crucial role in the pathogenesis of CD.