Bircan A, et al. - Researchers aimed to better understand the biology of lung cancer and identify novel therapeutic targets for developing highly effective molecularly targeted therapies for lung cancer. They evaluated viability, proliferation and metastatic ability of lung cancer cells via methylthiazoltetrazolium (MTT), colony formation and matrigel invasion assays, respectively. In addition, they carried out Western blotting, RT-PCR, and gene knockdown by siRNA transfections to investigate the effects of eEF-2K on lung cancer cells. Lung cancer cells displayed significant upregulation of eEF-2K. Tumor growth and invasion/metastasis ability of lung cancer cells was enhanced in relation to eEF-2K. Results suggest, for the first time, that patients with lung cancer have shorter overall survival in relation to high eEF-2K expression. They suggest eEF-2K could be a potential therapeutic target in lung cancer.