Gong Y, Chen LJ, Pang CP, et al. - In the present study, the researchers sought to examine photoreceptor degeneration in retinitis pigmentosa (RP) by quantitatively analyzing optical intensity of ellipsoid zone (EZ) on optical coherence tomography (OCT). In 24 eyes of 24 RP patients and 30 eyes of 30 healthy controls, they conducted OCT line scans of the horizontal meridian and obtained longitudinal reflectance profiles using ImageJ at every 5 pixels. In all patients, the optical intensity of EZ variation followed a similar pattern. The optical intensity of EZ measured by OCT can serve as a biomarker for early detection of degeneration of photoreceptors in RP.