Contreras JA, et al. - Given the mediatory role of volume treated with postoperative radiation therapy (PORT) in toxicity, and that decreased volumes result in improved quality of life (QOL), researchers conducted this phase II trial reducing treatment volumes by omitting PORT to the pathologically negative (PN0) neck in patients with primary head and neck squamous cell carcinoma. Eligible patients were those with head and neck squamous cell carcinoma who underwent surgical resection and neck dissection with a PN0 neck and high-risk features mandating PORT to the primary and/or involved neck. Oral cavity (n=14), oropharynx (n=37), hypopharynx (n=4), larynx (n=16), and unknown primary tumor (n = 1) were the included sites. The unirradiated neck showed excellent control rates after eliminating PORT to the PN0 neck without long-term adverse effects on global QOL.