Chen CH, et al. - In nasopharyngeal carcinoma (NPC), the role and underlying mechanism of ELF-1 (a member of the ETS family of transcription factors that regulate genes implicated in cellular growth) were studied in this analysis. Researchers used MTT, BrdU incorporation, and Transwell assays, to determine biological functions of ELF-1 in NPC cells. They analyzed CCL2/CCR2 signaling by Western blotting, ELISA, siRNAs, and CCR2 antagonist, to know about the mechanism of ELF-1 in NPC. Promotion of NPC cell proliferation, BrdU incorporation, migration, invasion and cisplatin resistance was noted because of gain-of-function of ELF-1 in TW01 and TW04 cells. By contrast, opposite outcomes were evident due to knockdown of ELF-1. Findings are suggestive of an oncogenic role of ELF-1 in NPC development related to the CCL2/CCR2 signaling pathway. ELF-1 is, thus, suggested as a potential target for NPC therapy.