Szirmay B, et al. - Researchers analyzed 86 patients with Crohn’s disease (CD) and 68 healthy individuals (control group) and categorized them according to their clinical scores (Harvey-Bradshaw Index [HBI] or Pediatric Crohn's Disease Activity Index [PCDAI]) to examine urinary concentrations of orosomucoid (u-ORM) in association with inflammatory activity of CD and compare it with clinical criteria and traditional laboratory parameters. They determined urinary u-ORM by automated immune turbidimetric assay, and values were referred to urinary creatinine (u-ORM/u-CREAT, mg/mmol). They and observed U-ORM/u-CREAT values seven times greater in children with active CD and two times greater in adults vs those with inactive disease. They noted an association of U-ORM/u-CREAT with conventional inflammatory markers (hs-CRP, serum ORM) and activity indices (HBI, P=0.018; PCDAI).