Salter L, et al. - In the present study, the researchers tested the premise that platelet counts might be elevated in children with moderate-severe osteogenesis imperfecta (OI) via analyzing data of 71 children with moderate-severe OI, treated in the Sheffield Children’s Hospital’s Severe, Complex and Atypical Osteogenesis Imperfecta Highly Specialised Service. For children with new or existing vertebral fractures, elevated platelet counts were recorded most often, but also (41%–44%) in the absence of identified proinflammatory factors or events. The outcomes suggested that these findings prove for a proinflammatory component to OI that could be a target for therapeutic intervention.