Zhu Y, et al. - In this Mendelian Randomization (MR) analysis by an inverse-weighted (IVW) method, researchers focused on the causal link between platelets and the risk of lung cancer. They used summary data from a recent publication including 48,666 Caucasian Europeans and International Lung Cancer Consortium and Transdisciplinary Research in Cancer of the Lung data consisting of 29,266 cases and 56,450 controls. In multiple instrumental variable analysis incorporating six single nucleotide polymorphisms (SNPs), they observed a 62% increased risk of overall NSCLC and 200% increased risk for small cell lung cancer, respectively. Only a trending association with NSCLC histological subtypes was demonstrated. These findings were retained in a series of sensitivity analysis. Overall, a causal link between elevated platelet count and increased risk of lung cancer was suggested. For possible anti-platelet interventions for lung cancer prevention, evidence was obtained in this study.