Balogun KA, et al. – This study was planned to investigate the association between protease inhibitor (PI)–based combination antiretroviral therapy (cART) and estradiol levels in pregnancy. Researchers realized an association of PI–cART exposure in pregnancy with elevated levels of estradiol, likely driven by higher fetal DHEAS production. Cord estradiol levels seemed to have an inverse correlation with birth weight centile in infants born to PI–cART exposed women, suggesting that fetal exposure to high estradiol levels may be contributing to cART–associated fetal growth restriction.