Mitchell DM, et al. - Researchers conducted this cross-sectional comparison to assess differences in skeletal microarchitecture between girls (n = 62; aged 10 to 16 years) with type 1 diabetes (T1D) and controls (n= 61) and to evaluate factors correlated with these differences. According to findings, areal bone mineral density (BMD) calculated by dual-energy x-ray absorptiometry did not vary between girls with and without T1D. Early in the course of illness and for those with higher average glycemia, skeletal microarchitecture in T1D is altered. Suppressed bone formation and lower circulating IGF-1 are likely to contribute to this phenotype.