Zhang X, et al. - Via the present study, researchers investigated how angiogenic factor with G-patch and FHA domains 1 (AGGF1) affects the prognosis and metastasis in colorectal cancer (CRC) patients. In a tissue microarray containing 236 CRC specimens and paired normal mucosae, they examined the expression level of AGGF1 in CRC by qPCR, western blot and immunohistochemistry. No significant difference was observed in the expression level of AGGF1 in CRC tissue and adjacent normal mucosa at the mRNA level. However, at the protein level, significantly higher AGGF1 expression was noted in CRC tissues than in paired normal mucosa, which showed a clear correlation with TNM stage, AJCC stage, vascular invasion, and differentiation. Further, an apparent correlation was observed between AGGF1 expression and poorer disease-free survival and overall survival of CRC patients. In addition, AGGF1 was noted to significantly promoting CRC cell wound healing, migration, and invasion in vitro and distant metastasis in vivo. These findings provide a base on which to investigate the utilization of AGGF1 as a potential therapeutic target for CRC patients, particularly for CRC patients with distant metastasis.