Mouhat B, Besutti M, Bouiller K, et al. - Given a tendency towards venous thromboembolism in cases with COVID-19, researchers sought for factors independently linked with computed tomography pulmonary angiography (CTPA)-confirmed pulmonary embolism (PE) in hospitalized severe COVID-19 patients. Among 349 cases hospitalized for COVID-19 in a university hospital in a French region with a high rate of COVID-19, 162 cases (46.4%) underwent CTPA (mean age 65.6±13.0; 67.3% males (95% confidence interval (CI) 59.5–75.5%)). Forty-four cases (27.2%) were diagnosed with PE. Observations suggest predictive value of elevated D-dimers (> 2590 ng·mL−1) and absence of anticoagulant therapy for PE in hospitalized COVID-19 cases with clinical signs of severity. Data thereby are in favor of the evidence base supporting systematic anticoagulation, and indicate wider use of D-dimer guided CTPA to screen for PE in acutely ill hospitalized cases with COVID-19.