Yan W, Liu J, Liu H, et al. - A total of 355 old individuals who were admitted with chronic heart failure (CHF, is the end stage of most cardiovascular diseases, is highly prevailing in old population and is related to high morbidity and mortality globally) were investigated in order to study the relationship in old people with CHF. The D-dimer was recognized as a risk factor for chronic kidney disease. Further reviews exhibited that independent of the subtype of heart failure (comprising heart failure with decreased ejection fraction and heart failure with maintained ejection fraction), higher D-dimer levels were related to a heightened risk of all-cause death. Hence, in elderly people with CHF, measurement of D-dimer levels could aid in risk stratification in these individuals, and high D-dimer levels might be considered as a caution sign to escalate therapy.