Dang TD, et al. - Researchers investigated if current methods to diagnose various egg allergy phenotypes could be improved with egg component resolved diagnostic (CRD). They also investigated whether egg CRD could serve as a predictor of the development of tolerance to egg. They used ImmunoCAP to measure serum egg white, Gal d 1, 2, 3 and 5 specific IgE (sIgE) in the HealthNuts cohort of 451 food challenge-proven egg allergic and egg-sensitized and egg-tolerant, age-matched 12-month infants with longitudinal follow-up at 2 and 4 years. By 2.5-fold increase in the risk of persistent egg allergy was caused by Gal d 1 sensitization. A fourfold increase in the risk of having persistent raw egg allergy was noted as a result of the production of sIgE to all four egg allergens (Gal d 1, 2, 3 or 5). Overall, findings were suggestive of the possible prognostic role of sensitization to multiple egg allergens Gal d 1, 2, 3 or 5, with utility for patient management and for detecting subjects at risk of developing persistent egg allergy.