Song X, et al. - In order to know about the roles EGFR and STAT3 play in the development and progression of breast cancer, researchers undertook this study. They used breast cancer tissue to recognize differently expressed genes including EGFR and STAT3, via bioinformatics analysis. To inquire about EGFR and STAT3 levels in breast cancer tissues and cells, they used QRT-PCR and Western blot analysis. In breast cancer tissues and cell lines, they found the upregulation of both EGFR and p-STAT3. A positive link of EGFR expression with p-STAT3 was revealed. Enhanced proliferation and invasion of tumor cells was brought about by EGFR and p-STAT3 activity. Overall, through STAT3 phosphorylation and JAK/STAT3 signaling, EGFR induced promotion of breast cancer progression.