Lipton RB, et al. - Researchers examined if relative to placebo, 120 mg DFN-15, an oral, ready-made liquid solution of celecoxib, is efficacious, tolerable, and safe for the acute treatment of migraine. In this randomized, double-blind, placebo-controlled, 567 adults treated a migraine with 120 mg DFN-15 or placebo as soon as possible after the onset of pain of moderate to severe intensity. Outcomes revealed significantly higher efficacy of DFN-15 vs placebo for the acute treatment of migraine, with a generally favorable tolerability and safety profile.