Dominiak M, Antosik-Wójcińska AZ, Goetz Z, et al. - Electroconvulsive therapy (ECT) is reported to be the most effective treatment of depression, however, uncertainty remains concerning the type that is most beneficial. in patients with bipolar or unipolar depression, researchers here compared the effectiveness, safety, and tolerability of the formula-based right unilateral ECT (RUL) vs the fronto-temporal bilateral ECT (BT). They randomly assigned 91 patients to either BT (n = 45) or RUL (n = 46) ECT. Brief pulse width (0.5 ms) and a formula-based dosing method were applied. When using higher doses of energy in RUL ECT, the groups did not differ significantly in outcomes of effectiveness. Overall findings suggest no difference between formula-based RUL ECT and BT in terms of antidepressant efficacy may be being advantageous in terms of safety (lower incidence of increased blood pressure and fewer disturbances of consciousness) and tolerability (impact on cognitive functions).