Köse ÖK, et al. - Since melasma is a common, multifactorial, and recurring disease that is not easy to treat, researchers sought to assess the effectiveness of microneedling in combination with Q‐switched neodymium‐doped yttrium aluminum garnet laser (QsNd‐YAG laser) for the treatment of melasma. Participants in the study were 15 female patients with epidermal or mixed‐type melasma on the face. Patients were first treated at the same session with the QsNd-YAG laser and then with microneedling containing biomimetic peptide mesotherapy products. Before the first session and again 2 weeks after the last session, Modified Melasma Area Severity Index (mMASI) scores were calculated. After completion of the protocol, mMASI scores were significantly reduced. In addition to the use of photoprotective measures, multimodality treatment including QsNd-YAG laser and microneedling with mesotherapy products containing biomimetic peptides is effective in the treatment of melasma and works synergistically.