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Efficacy of the combination of pinaverium bromide 100 mg plus simethicone 300 mg in abdominal pain and bloating in irritable bowel syndrome: A randomized, placebo-controlled trial

Journal of Clinical Gastroenterology Aug 08, 2019

Schmulson MJ, Chiu-Ugalde J, Sáez-Ríos A, et al. - In patients with irritable bowel syndrome (IBS), a multifactorial disorder, researchers tested the safety and effectiveness of PB+S (pinaverium bromide 100 mg plus simethicone 300 mg). In this 12-week, randomized, double-blind, placebo-controlled study of PB+S vs placebo BID, IBS-Rome III patients with abdominal pain/discomfort for at least 2 days within the week prior to baseline assessment were involved. The study sample consisted of 285 patients received at least 1 dose of PB+S (n = 140) or placebo (n = 145). There was no difference in the overall improvement of symptoms between groups. However, in abdominal pain and bloating, PB+S was superior. IBS-C and IBS-M patients displayed the best improvement in the frequency of stool types with PB+S. In IBS Quality of Life scores and adverse events, no differences were observed.
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