Kim J, et al. - Through a group of patients who were scheduled to undergo TKA, researchers ascertained the efficacy of administration on one day postoperatively. For 48 h post-TKA, postoperative pain and nausea prevailed to be high. Group 1 (who received 10 mg dexamethasone intravenously one hour prior to the surgery) had lower pain and nausea visual analogue scale (VAS) scores vs the control group for only 24 h post-TKA. Groups 2 (received 0.1 mg/kg dexamethasone 24 h following surgery) and 3 (received 0.2 mg/kg dexamethasone 24 h following surgery) vs the control group and group 1 had lower pain and nausea VAS scores 48 h post-TKA. In groups 2 and 3 vs the control group, during 48 h following TKA, analgesic and antiemetic administration were significantly lower. No variations in CRP level and range of motion were noted, and complications were not identified. Hence, for controlling pain and nausea, the impact of pre- and postoperative administration of dexamethasone was noted only for 24h. Further administration of dexamethasone at one day postoperatively is recommended, taking severe pain and nausea continuity for more than 48h following TKA into account.