Meske DS, et al. - Researchers evaluated opioids’ efficacy in chronic non-cancer pain via conducting a meta-analysis of published clinical trials for μ-opioid receptor agonists performed for US Food and Drug Administration approval. Randomized controlled trials suggested opioids to be efficacious in the treatment of chronic non-cancer pain for up to 3 months. Opioid showed minor benefits on physical function and no effect on mental function. They recommended considering the findings, alongside data on opioid safety, in the use of opioids for the treatment of chronic pain.