Stewart JR, et al. - For treating squamous cell carcinoma in situ (SCCIS) and squamous cell carcinoma (SCC), electrodessication and cryotherapy in combination with curettage are more effective than photodynamic therapy, 5-flurouracil, or imiquimod.

• SCCIS and SCC treated with 5-fluorouracil, imiquimod, electrodessication, curettage, photodynamic therapy, ablative lasers, or cryotherapy were the subjects of a systematic review and meta-analysis.

• One hundred eighty-six studies describing the treatment of 9,336 tumors were included.

• SCC and SCCIS recurrence rates were lower after electrodessication with curettage or cryotherapy with curettage than after other treatments like photodynamic therapy, 5-fluorouracil, or imiquimod.