Koster MJ, et al. - In a large single-institution cohort of patients with giant cell arteritis (GCA), researchers determined the effect of methotrexate (MTX) on the risk of relapse and glucocorticoid (GC) use. Confirmed evidence of temporal artery biopsy and/or radiographic evidence of large vessel vasculitis was identified in patients diagnosed with GCA from 1998 to 2013. Eighty-three cases were identified and compared with 83 controls. No significant differences were observed in age, demographics, laboratory variables, baseline disease characteristics, or mean initial dose of prednisone. The addition of MTX to GC reduced the rate of subsequent relapse by nearly 2-fold vs patients taking GC alone in this large single-institution cohort. In patients with GCA, MTX can be considered as an adjunct therapy to reduce the risk of further relapse events.