Kato H, et al. - The effectiveness of combination 5-fluorouracil (500 mg/body 7 days/week) and cisplatin (5 mg/body 5 days/week) in the treatment of invasive extramammary Paget's disease (EMPD) was deternubed, Results revealed a low risk and relatively high disease control rate by the use of this regimen. In cases of advanced EMPD, this combination drug us recommended as one treatment option.